Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 years of excellence.

ThisCentennial Issue of the Journal ofMedicinal Chemistry was conceived in order to commemorate the 100th anniversary of the Division of Medicinal Chemistry. The Journal is a fitting venue for this tribute. For the past 50 years, the Journal has been considered the flagship publication in our field anda rich repositoryof scientific advancement in the area of drug discovery. Thus, although the Journal and the Division have never been formally linked, they are inextricably united by a desire to advance the practice of medicinal chemistry. It is arguably fitting for me to write this foreword, since the formation of the Division of Medicinal Chemistry occurred less than amile fromwhere I now sit. The changes in the world, the field of medicinal chemistry, and the Division over the past 100 years have been nothing less than spectacular.